Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults: a cohort study.

ABSTRACT:

Background

Circulating concentrations of 25-hydroxyvitamin D [25-(OH)D] are used to define vitamin D deficiency. Current clinical 25-(OH)D targets based on associations with intermediate markers of bone metabolism may not reflect optimal levels for other chronic diseases and do not account for known seasonal variation in 25-(OH)D concentration.

Objective

To evaluate the relationship of 25-(OH)D concentration with the incidence of major clinical disease events that are pathophysiologically relevant to vitamin D.

Design

Cohort study.

Setting

The Cardiovascular Health Study conducted in 4 U.S. communities. Data from 1992 to 2006 were included in this analysis.

Participants

1621 white older adults.

Measurements

Serum 25-(OH)D concentration (using a hi

SUBMITTER: de Boer IH 

PROVIDER: S-EPMC3632351 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature