Slits affect the timely migration of neural crest cells via Robo receptor.

ABSTRACT:

Background

Neural crest cells emerge by delamination from the dorsal neural tube and give rise to various components of the peripheral nervous system in vertebrate embryos. These cells change from non-motile into highly motile cells migrating to distant areas before further differentiation. Mechanisms controlling delamination and subsequent migration of neural crest cells are not fully understood. Slit2, a chemorepellant for axonal guidance that repels and stimulates motility of trunk neural crest cells away from the gut has recently been suggested to be a tumor suppressor molecule. The goal of this study was to further investigate the role of Slit2 in trunk neural crest cell migration by constitutive expression in neural crest cells.

Results

We found that Slit gain-of-funct

SUBMITTER: Giovannone D 

PROVIDER: S-EPMC3632352 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature