Identifying loci under selection against gene flow in isolation-with-migration models.

ABSTRACT: When divergence occurs in the presence of gene flow, there can arise an interesting dynamic in which selection against gene flow, at sites associated with population-specific adaptations or genetic incompatibilities, can cause net gene flow to vary across the genome. Loci linked to sites under selection may experience reduced gene flow and may experience genetic bottlenecks by the action of nearby selective sweeps. Data from histories such as these may be poorly fitted by conventional neutral model approaches to demographic inference, which treat all loci as equally subject to forces of genetic drift and gene flow. To allow for demographic inference in the face of such histories, as well as the identification of loci affected by selection, we developed an isolation-with-migration model tha

SUBMITTER: Sousa VC 

PROVIDER: S-EPMC3632470 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature