Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection.

ABSTRACT:

Background

H1N1 influenza viruses were responsible for the 1918 pandemic that caused millions of deaths worldwide and the 2009 pandemic that caused approximately twenty thousand deaths. The cellular response to such virus infections involves extensive genetic reprogramming resulting in an antiviral state that is critical to infection control. Identifying the underlying transcriptional network driving these changes, and how this program is altered by virally-encoded immune antagonists, is a fundamental challenge in systems immunology.

Results

Genome-wide gene expression patterns were measured in human monocyte-derived dendritic cells (DCs) infected in vitro with seasonal H1N1 influenza A/New Caledonia/20/1999. To provide a mechanistic explanation for the timing of gene expres

SUBMITTER: Zaslavsky E 

PROVIDER: S-EPMC3633009 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature