State of art fusion-finder algorithms are suitable to detect transcription-induced chimeras in normal tissues?

ABSTRACT:

Background

RNA-seq has the potential to discover genes created by chromosomal rearrangements. Fusion genes, also known as "chimeras", are formed by the breakage and re-joining of two different chromosomes. It is known that chimeras have been implicated in the development of cancer. Few publications in the past showed the presence of fusion events also in normal tissue, but with very limited overlaps between their results. More recently, two fusion genes in normal tissues were detected using both RNA-seq and protein data.Due to heterogeneous results in identifying chimeras in normal tissue, we decided to evaluate the efficacy of state of the art fusion finders in detecting chimeras in RNA-seq data from normal tissues.

Results

We compared the performance of six fusion-finder t

SUBMITTER: Carrara M 

PROVIDER: S-EPMC3633050 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature