The short-term effects of vitamin D repletion on cholesterol: a randomized, placebo-controlled trial.

ABSTRACT:

Objective

Vitamin D deficiency is common and associated with dyslipidemia. However, it is unclear whether oral vitamin D supplementation improves the lipid profile. Therefore, we conducted a randomized, placebo-controlled trial to determine the short-term effects of vitamin D repletion on the lipid profile.

Methods and results

One hundred fifty-one vitamin D-deficient (25-hydroxyvitamin D <20 ng/mL) adults with elevated risk for cardiovascular disease were randomized to receive either 50 000 IU of vitamin D3 weekly for 8 weeks or placebo. The primary outcome was the change in small low-density lipoprotein (LDL) particle number. Secondary outcomes included changes in other nuclear magnetic resonance-based and chemical lipid fractions. Vitamin D failed to improve the lipid pro

SUBMITTER: Ponda MP 

PROVIDER: S-EPMC3633472 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature