Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells.

ABSTRACT:

Introduction

The role of miRNAs in acquired endocrine-resistant breast cancer is not fully understood. One hallmark of tumor progression is epithelial-to-mesenchymal transition (EMT), characterized by a loss of cell adhesion resulting from reduced E-cadherin and increased cell mobility. miR-200 family members regulate EMT by suppressing expression of transcriptional repressors ZEB1/2. Previously we reported that the expression of miR-200a, miR-200b, and miR-200c was lower in LY2 endocrine-resistant, mesenchymal breast cancer cells compared to parental, endocrine sensitive, epithelial MCF-7 breast cancer cells. Here we investigated the regulation of miR-200 family members and their role in endocrine-sensitivity in breast cancer cells.

Results

miR-200 family expression was pro

SUBMITTER: Manavalan TT 

PROVIDER: S-EPMC3633860 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature