Interferon-beta induces distinct gene expression response patterns in human monocytes versus T cells.

ABSTRACT:

Background

Monocytes, which are key players in innate immunity, are outnumbered by neutrophils and lymphocytes among peripheral white blood cells. The cytokine interferon-β (IFN-β) is widely used as an immunomodulatory drug for multiple sclerosis and its functional pathways in peripheral blood mononuclear cells (PBMCs) have been previously described. The aim of the present study was to identify novel, cell-specific IFN-β functions and pathways in tumor necrosis factor (TNF)-α-activated monocytes that may have been missed in studies using PBMCs.

Methodology/principal findings

Whole genome gene expression profiles of human monocytes and T cells were compared following in vitro priming to TNF-α and overnight exposure to IFN-β. Statistical analyses of the gene expression data re

SUBMITTER: Henig N 

PROVIDER: S-EPMC3633862 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature