Vaccination against influenza with recombinant hemagglutinin expressed by Schizochytrium sp. confers protective immunity.

ABSTRACT: For the rapid production of influenza vaccine antigens in unlimited quantities, a transition from conventional egg-based production to cell-based and recombinant systems is required. The need for higher-yield, lower-cost, and faster production processes is critical to provide adequate supplies of influenza vaccine to counter global pandemic threats. In this study, recombinant hemagglutinin proteins of influenza virus were expressed in the microalga Schizochytrium sp., an established, fermentable organism grown in large scale for the manufacture of polyunsaturated fatty acids for animal and human health applications. Schizochytrium was capable of exporting the full-length membrane-bound proteins in a secreted form suitable for vaccine formulation. One recombinant hemagglutinin (rHA) protein

SUBMITTER: Bayne AC 

PROVIDER: S-EPMC3634000 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature