Characteristics of idiosyncratic drug-induced liver injury in children: results from the DILIN prospective study.

ABSTRACT:

Background

The spectrum and severity of idiosyncratic drug-induced liver injury (DILI) in children are not well established.

Patients and methods

The DILIN (Drug-Induced Liver Injury Network) Prospective Study is a longitudinal multicenter study designed to determine the etiologies, risk factors, and outcomes of suspected DILI. Between September 2004 and September 2009, 30 children ages 2 to 18 years with suspected DILI who met eligibility criteria were enrolled and studied for at least 6 months.

Results

Mean age was 14 years; 70% were girls. Antimicrobial (50%) and central nervous system agents (40%) were the most commonly implicated drug classes, with minocycline (4), isoniazid (3), azithromycin (3), atomoxetine (3), and lamotrigine (3) the leading agents. Median ti

SUBMITTER: Molleston JP 

PROVIDER: S-EPMC3634369 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature