Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia.

ABSTRACT: Obesity is a complex metabolic disorder that often manifests with a strong genetic component in humans. However, the genetic basis for obesity and the accompanying metabolic syndrome is poorly defined. At a metabolic level, obesity arises from an imbalance between the nutritional intake and energy utilization of an organism. Mechanisms that sense the metabolic state of the individual and convey this information to satiety centers help achieve this balance. Mutations in genes that alter or modify such signaling mechanisms are likely to lead to either obese individuals, who in mammals are at high risk for diabetes and cardiovascular disease, or excessively thin individuals with accompanying health problems. Here we show that Drosophila mutants for an intracellular calcium signaling channel,

SUBMITTER: Subramanian M 

PROVIDER: S-EPMC3634656 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature