Sex bias in infectious disease epidemiology: patterns and processes.

ABSTRACT:

Background

Infectious disease incidence is often male-biased. Two main hypotheses have been proposed to explain this observation. The physiological hypothesis (PH) emphasizes differences in sex hormones and genetic architecture, while the behavioral hypothesis (BH) stresses gender-related differences in exposure. Surprisingly, the population-level predictions of these hypotheses are yet to be thoroughly tested in humans.

Methods and findings

For ten major pathogens, we tested PH and BH predictions about incidence and exposure-prevalence patterns. Compulsory-notification records (Brazil, 2006-2009) were used to estimate age-stratified ♂:♀ incidence rate ratios for the general population and across selected sociological contrasts. Exposure-prevalence odds ratios were derived f

SUBMITTER: Guerra-Silveira F 

PROVIDER: S-EPMC3634762 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature