The susceptibility of Pseudomonas aeruginosa strains from cystic fibrosis patients to bacteriophages.

ABSTRACT: Phage therapy may become a complement to antibiotics in the treatment of chronic Pseudomonas aeruginosa infection. To design efficient therapeutic cocktails, the genetic diversity of the species and the spectrum of susceptibility to bacteriophages must be investigated. Bacterial strains showing high levels of phage resistance need to be identified in order to decipher the underlying mechanisms. Here we have selected genetically diverse P. aeruginosa strains from cystic fibrosis patients and tested their susceptibility to a large collection of phages. Based on plaque morphology and restriction profiles, six different phages were purified from "pyophage", a commercial cocktail directed against five different bacterial species, including P. aeruginosa. Characterization of these phages by elec

SUBMITTER: Essoh C 

PROVIDER: S-EPMC3634792 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature