Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila.

ABSTRACT: After injury to the animal epidermis, a variety of genes are transcriptionally activated in nearby cells to regenerate the missing cells and facilitate barrier repair. The range and types of diffusible wound signals that are produced by damaged epidermis and function to activate repair genes during epidermal regeneration remains a subject of very active study in many animals. In Drosophila embryos, we have discovered that serine protease function is locally activated around wound sites, and is also required for localized activation of epidermal repair genes. The serine protease trypsin is sufficient to induce a striking global epidermal wound response without inflicting cell death or compromising the integrity of the epithelial barrier. We developed a trypsin wounding treatment as an ampli

SUBMITTER: Patterson RA 

PROVIDER: S-EPMC3634835 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature