Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women.

ABSTRACT:

Introduction

Changes in sex hormones with weight loss might have implications for breast cancer prevention but have not been examined extensively, particularly in African-American (AA) women.

Methods

We conducted a prospective study of 278 overweight/obese postmenopausal women (38% AA) not taking hormone therapy within the Weight Loss Maintenance Trial. All participants lost at least 4 kg after a 6-month weight-loss phase and attempted to maintain weight loss during the subsequent 12 months. We evaluated the percentage changes in estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate and sex hormone-binding globulin (SHBG) using generalized estimating equations.

Results

In all study phases, AA women had hig

SUBMITTER: Stolzenberg-Solomon RZ 

PROVIDER: S-EPMC3635052 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature