Analgesia and central side-effects: two separate dimensions of morphine response.

ABSTRACT:

Aims

To present a statistical model for defining interindividual variation in response to morphine and to use this model in a preliminary hypothesis-generating multivariate genetic association study.

Methods

Two hundred and sixty-four cancer patients taking oral morphine were included in a prospective observational study. Pain and morphine side-effect scores were examined using principal components analysis. The resulting principal components were used in an exploratory genetic association study of single nucleotide polymorphisms across the genes coding for the three opioid receptors, OPRM1, OPRK1 and OPRD1. Associations in multivariate models, including potential clinical confounders, were explored.

Results

Two principal components corresponding to residual pain and

SUBMITTER: Droney JM 

PROVIDER: S-EPMC3635604 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature