Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells.

ABSTRACT:

Rationale

The mechanism by which endogenous progenitor cells contribute to functional and beneficial effects in stem cell therapy remains unknown.

Objective

Utilizing a novel (31)P magnetic resonance spectroscopy-2-dimensional chemical shift imaging method, this study examined the heterogeneity and bioenergetic consequences of postinfarction left ventricular (LV) remodeling and the mechanisms of endogenous progenitor cell contribution to the cellular therapy.

Methods and results

Human embryonic stem cell-derived vascular cells (hESC-VCs) that stably express green fluorescent protein and firefly luciferase (GFP(+)/Luc(+)) were used for the transplantation. hESC-VCs may release various cytokines to promote angiogenesis, prosurvival, and antiapoptotic effects. Both in vi

SUBMITTER: Xiong Q 

PROVIDER: S-EPMC3635674 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature