Cytokine genetic variations and fatigue among patients with breast cancer.

ABSTRACT:

Purpose

Fatigue is a common adverse effect of cancer treatment and may persist for years after treatment completion. However, risk factors for post-treatment fatigue have not been determined. On the basis of studies suggesting an inflammatory basis for fatigue, this study tested the hypothesis that expression-regulating polymorphisms in proinflammatory cytokine genes would predict post-treatment fatigue in breast cancer survivors.

Patients and methods

Women diagnosed with early-stage breast cancer (n = 171) completed questionnaires to assess fatigue and other behavioral symptoms (ie, depressive symptoms, memory complaints, sleep disturbance) and provided blood for genotyping within 3 months after primary treatment. Genomic DNA was extracted from peripheral-blood leukocytes a

SUBMITTER: Bower JE 

PROVIDER: S-EPMC3635681 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature