Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias.

ABSTRACT:

Background

Life-threatening cardiac arrhythmia is a major source of mortality worldwide. Besides rare inherited monogenic diseases such as long-QT or Brugada syndromes, which reflect abnormalities in ion fluxes across cardiac ion channels as a final common pathway, arrhythmias are most frequently acquired and associated with heart disease. The mineralocorticoid hormone aldosterone is an important contributor to morbidity and mortality in heart failure, but its mechanisms of action are incompletely understood.

Methods and results

To specifically assess the role of the mineralocorticoid receptor (MR) in the heart, in the absence of changes in aldosteronemia, we generated a transgenic mouse model with conditional cardiac-specific overexpression of the human MR. Mice exhibit a h

SUBMITTER: Ouvrard-Pascaud A 

PROVIDER: S-EPMC3635833 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature