Physical activity and the association of common FTO gene variants with body mass index and obesity.

ABSTRACT:

Background

Common FTO (fat mass and obesity associated) gene variants have recently been associated with body mass index (BMI) and obesity in several large studies. The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown.

Methods

To determine if FTO variants are associated with BMI in Old Order Amish (OOA) individuals, and to further determine whether the detrimental associations of FTO gene variants can be lessened by increased physical activity, a total of 704 healthy OOA adults were selected from the Heredity and Phenotype Intervention (HAPI) Heart Study, an investigation of gene x environment interactions in cardiovascular disease, for whom objective quantified physical activity measurements were availab

SUBMITTER: Rampersaud E 

PROVIDER: S-EPMC3635949 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature