Conserved expression of natural antisense transcripts in mammals.

ABSTRACT:

Background

Recent studies had found thousands of natural antisense transcripts originating from the same genomic loci of protein coding genes but from the opposite strand. It is unclear whether the majority of antisense transcripts are functional or merely transcriptional noise.

Results

Using the Affymetrix Exon array with a modified cDNA synthesis protocol that enables genome-wide detection of antisense transcription, we conducted large-scale expression analysis of antisense transcripts in nine corresponding tissues from human, mouse and rat. We detected thousands of antisense transcripts, some of which show tissue-specific expression that could be subjected to further study for their potential function in the corresponding tissues/organs. The expression patterns of many an

SUBMITTER: Ling MH 

PROVIDER: S-EPMC3635984 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature