Race and gender variation in response to evoked inflammation.

ABSTRACT:

Background

Race- and gender-variation in innate immunity may contribute to demographic differences in inflammatory and cardiometabolic disease; yet their influence on dynamic responses during inflammatory stress is poorly understood. Our objective was to examine race and gender influence on the response to experimental endotoxemia.

Methods

The Genetics of Evoked Responses to Niacin and Endotoxemia (GENE) study was designed to investigate regulation of inflammatory and metabolic responses during low-grade endotoxemia (LPS 1 ng/kg intravenously) in healthy individuals (median age 24, IQR=7) of European (EA; n=193, 47% female) and African ancestry (AA; n=101, 59% female).

Results

Baseline clinical, metabolic, and inflammatory biomarkers by race and gender were consistent

SUBMITTER: Ferguson JF 

PROVIDER: S-EPMC3636014 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature