Dynamic regulation of epigenomic landscapes during hematopoiesis.

ABSTRACT:

Background

Human blood develops from self-renewing hematopoietic stem cells to terminal lineages and necessitates regulator and effector gene expression changes; each cell type specifically expresses a subset of genes to carry out a specific function. Gene expression changes coincide with histone modification, histone variant deposition, and recruitment of transcription-related enzymes to specific genetic loci. Transcriptional regulation has been mostly studied using in vitro systems while epigenetic changes occurring during in vivo development remain poorly understood.

Results

By integrating previously published and novel global expression profiles from human CD34+/CD133+ hematopoietic stem and progenitor cells (HSPCs), in vivo differentiated human CD4+ T-cells and CD19+ B-

SUBMITTER: Abraham BJ 

PROVIDER: S-EPMC3636055 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature