Phylogeny of bacterial and archaeal genomes using conserved genes: supertrees and supermatrices.

ABSTRACT: Over 3000 microbial (bacterial and archaeal) genomes have been made publically available to date, providing an unprecedented opportunity to examine evolutionary genomic trends and offering valuable reference data for a variety of other studies such as metagenomics. The utility of these genome sequences is greatly enhanced when we have an understanding of how they are phylogenetically related to each other. Therefore, we here describe our efforts to reconstruct the phylogeny of all available bacterial and archaeal genomes. We identified 24, single-copy, ubiquitous genes suitable for this phylogenetic analysis. We used two approaches to combine the data for the 24 genes. First, we concatenated alignments of all genes into a single alignment from which a Maximum Likelihood (ML) tree was infer

SUBMITTER: Lang JM 

PROVIDER: S-EPMC3636077 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature