Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure.

ABSTRACT: Lassa virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with LASV leads to the development of hemorrhagic fever in a significant number of cases, and it is estimated that thousands die each year from the disease. Little is known about the complex immune mechanisms governing the response to LASV or the genetic determinants of susceptibility and resistance to infection. In the study presented here, we have used a whole-genome, microarray-based approach to determine the temporal host response in the peripheral blood mononuclear cells (PBMCs) of non-human primates (NHP) following aerosol exposure to LASV. Sequential sampling over the entire disease course showed that there are strong transcriptional changes of the immune response to LAS

SUBMITTER: Malhotra S 

PROVIDER: S-EPMC3636129 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature