Modulating water-exchange rates of lanthanide(III)-containing polyaminopolycarboxylate-type complexes using polyethylene glycol.

ABSTRACT: We have synthesized a series of Ln(III)-containing polyethylene glycol conjugates and studied the structural and electronic properties of these complexes. These studies demonstrate that polyethylene glycol can be used to fine-tune water-exchange rates of Ln(III)-containing polyaminopolycarboxylate-type complexes; this control is desirable in developing Ln(III)-containing contrast agents for magnetic resonance imaging.

SUBMITTER: Siriwardena-Mahanama BN 

PROVIDER: S-EPMC3636156 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature