Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma.

ABSTRACT:

Purpose

In humans, activation-induced cytidine deaminase (AID) expression results due to inflammation and this deaminase activity is also involved in carcinogenesis. The aim of this study is to investigate the correlation between AID expression and the clinical classification of oral cancer tissues.

Experimental design

The current study investigated the correlation between AID expression and the clinical classification of oral cancer tissues from 27 patients who underwent surgical resection using immunohistochemistry. Specific AID expression and its induction by cytokine stimulation were investigated in cultured HSC oral cancer cell lines by reverse transcriptase PCR.

Results

AID expression was detected in 10 of 27 specimens (37.0%). AID expression was more frequently

SUBMITTER: Nakanishi Y 

PROVIDER: S-EPMC3636261 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature