Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.

ABSTRACT:

Background

Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors. Recently, a genome-wide association study revealed an association between polymorphisms in the KIF1B gene and the risk of hepatocellular carcinoma (HCC), and several case-control studies have further investigated this relationship. However, these studies have yielded controversial results. We therefore performed a meta-analysis to derive a more precise estimation of the association between the KIF1B gene polymorphisms and HCC risk.

Methodology/principal finding

PubMed, EMBASE, the ISI Web of Science and the CNKI databases were systematically searched to identify relevant studies. A total of 5 studies containing 13 cohorts with 5,773 cases and 6,404 controls were inc

SUBMITTER: Wang ZC 

PROVIDER: S-EPMC3636275 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature