Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors.

ABSTRACT: Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes. However targeted delivery of siRNAs to tumor tissues and cells and more importantly, their intracellular release at sites of interest still remains a major challenge that needs to be addressed before this technique could become a clinically viable option. In the current study, we have engineered and screened a series of CD44 targeting hyaluronic acid (HA) based self-assembling nanosystems for targeted siRNA delivery. The HA polymer was functionalized with lipids of varying carbon chain lengths/nitrogen content, as well as polyamines for assessing siRNA encapsulation. From the screens, several HA-derivatives were identified that could stably encapsulate/co

SUBMITTER: Ganesh S 

PROVIDER: S-EPMC3636539 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature