MiRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers.

ABSTRACT:

Background

Based on their function in cancer micro(mi)RNAs are often grouped as either tumor suppressors or oncogenes. However, miRNAs regulate multiple tumor relevant signaling pathways raising the question whether two oncogenic miRNAs could be functional antagonists by promoting different steps in tumor progression. We recently developed a method to connect miRNAs to biological function by comparing miRNA and gene array expression data from the NCI60 cell lines without using miRNA target predictions (miRConnect).

Results

We have now extended this analysis to three primary human cancers (ovarian cancer, glioblastoma multiforme, and kidney renal clear cell carcinoma) available at the Cancer Genome Atlas (TCGA), and have correlated the expression of the clustered miRNAs with

SUBMITTER: Hua Y 

PROVIDER: S-EPMC3637148 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature