A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans.

ABSTRACT:

Background

Exposure to traffic-related air pollution (TRAP) is considered a trigger for acute cardiovascular events. Diesel Exhaust (DE) is a major contributor to TRAP in the world. We evaluated the effect of DE inhalation on circulating blood cell populations, hematological indices, and systemic inflammatory cytokines in humans using a specialized facility.

Methods

In a randomized double-blind crossover study balanced to order, 17 metabolic syndrome (MetS) and 15 healthy subjects inhaled filtered air (FA) or DE exposure in two-hour sessions on different days with a minimum 2-week washout period. We collected blood pre-exposure, 7, and 22 hours after exposure initiation and measured the complete blood count and differential. We performed multiplex cytokine assay to measure t

SUBMITTER: Krishnan RM 

PROVIDER: S-EPMC3637197 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature