Structural analysis and epitope prediction of HCV E1 protein isolated in Pakistan: an in-silico approach.

ABSTRACT:

Background

HCV infection is a major health problem causing acute and chronic hepatitis. HCV E1 protein is a transmembrane protein that is involved in viral attachment and therefore, can serve as an important target for vaccine development. Consequently, this study was designed to analyze the HCV E1 protein sequence isolated in Pakistan to find potential conserved epitopes/antigenic determinants.

Results

HCV E1 protein isolated in Pakistan was analyzed using various bio-informatics and immuno-informatics tools including sequence and structure tools. A total of four antigenic B cell epitopes, 5 MHC class I binding peptides and 5 MHC class II binding peptides were predicted. Best designed epitopes were subjected to conservation analyses with other countries.

Conclusion

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SUBMITTER: Idrees S 

PROVIDER: S-EPMC3637199 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature