Changes in circulating 25-hydroxyvitamin D according to vitamin D binding protein genotypes after vitamin D₃ or D₂supplementation.

ABSTRACT:

Background

It is not known whether genetic variation in the vitamin D binding protein (DBP) influences 25-hydroxyvitamin D levels [25(OH)D] after vitamin D supplementation. We aimed to investigate the changes of total 25(OH)D, 25(OH)D₃ and 25(OH)D₂ in a Thai cohort, according to type of vitamin D supplement (vitamin D₃ or D₂) and DBP genotype, after receiving vitamin D₃ or D₂ for 3 months.

Methods

Thirty-nine healthy subjects completed the study. All subjects received 400  IU of either vitamin D₃ or D₂, plus a calcium supplement, every day for 3 months. Total serum 25(OH)D, 25(OH)D₃ and 25(OH)D₂ were measured by LC-MS/MS. Individual genotyping of rs4588 in the DBP gene was performed using real-time PCR.

Results

Vitamin D₃ supplementation of 400  IU/d increased 25(OH)D

SUBMITTER: Nimitphong H 

PROVIDER: S-EPMC3637219 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature