Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies.

ABSTRACT:

Background

Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and inhibits glucagon secretion and gastric emptying. We investigated cardioprotective effects of lixisenatide in rodent models reflecting the clinical situation.

Methods

The acute cardiac effects of lixisenatide were investigated in isolated rat hearts subjected to brief ischemia and reperfusion. Effects of chronic treatment with lixisenatide on cardiac function were assessed in a modified rat heart failure model after only transient coronary occlusion followed by long-term reperfusion. Freshly isolated cardiomyocytes were used to investigate cell-type specific mechanisms of lixisenatide action.

Results

In the acute setting of ischemia-reperfusion, lixisenatide reduced the

SUBMITTER: Wohlfart P 

PROVIDER: S-EPMC3637243 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature