Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability.

ABSTRACT:

Background

Iron is an essential nutrient for almost all organisms, and generating iron limiting conditions for pathogens is one of the host defense strategies against microbial infections. Excess of iron can be toxic; therefore, iron uptake is tightly controlled. The high affinity iron uptake system of the opportunistic pathogenic yeast Candida albicans has been shown to be essential for virulence. Several transcription factors and regulators of iron uptake genes were identified, but the knowledge of signaling pathways is still limited. Gene expression profiling of the Δhog1 deletion mutant indicated an involvement of the mitogen activated protein (MAP) kinase Hog1p. However, the function of Hog1p in the response of C. albicans to iron availability was not studied in detail. Thus,

SUBMITTER: Kaba HE 

PROVIDER: S-EPMC3637358 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature