A systematic review of biomarkers for disease progression in Parkinson's disease.

ABSTRACT:

Background

Using surrogate biomarkers for disease progression as endpoints in neuroprotective clinical trials may help differentiate symptomatic effects of potential neuroprotective agents from true disease-modifying effects. A systematic review was undertaken to determine what biomarkers for disease progression in Parkinson's disease (PD) exist.

Methods

MEDLINE and EMBASE (1950-2010) were searched using five search strategies. Abstracts were assessed to identify papers meriting review in full. Studies of participants with idiopathic PD diagnosed by formal criteria or clearly described clinical means were included. We made no restriction on age, disease duration, drug treatment, or study design. We included studies which attempted to draw associations between any tests used

SUBMITTER: McGhee DJ 

PROVIDER: S-EPMC3637496 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature