Robust methods for population stratification in genome wide association studies.

ABSTRACT:

Background

Genome-wide association studies can provide novel insights into diseases of interest, as well as to the responsiveness of an individual to specific treatments. In such studies, it is very important to correct for population stratification, which refers to allele frequency differences between cases and controls due to systematic ancestry differences. Population stratification can cause spurious associations if not adjusted properly. The principal component analysis (PCA) method has been relied upon as a highly useful methodology to adjust for population stratification in these types of large-scale studies. Recently, the linear mixed model (LMM) has also been proposed to account for family structure or cryptic relatedness. However, neither of these approaches may be optima

SUBMITTER: Liu L 

PROVIDER: S-EPMC3637636 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature