Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies.

ABSTRACT:

Background

Microarray studies related to cystic fibrosis (CF) airway gene expression have gone some way in clarifying the complex molecular background of CF lung diseases, but have made little progress in defining a robust "molecular signature" associated with mutant CFTR expression. Disparate methodological and statistical analyses complicate comparisons between independent studies of the CF transcriptome, and although each study may be valid in isolation, the conclusions reached differ widely.

Methods

We carried out a small-scale whole genome microarray study of gene expression in human native nasal epithelial cells from F508del-CFTR homozygotes in comparison to non-CF controls. We performed superficial comparisons with other microarray datasets in an attempt to identify a

SUBMITTER: Clarke LA 

PROVIDER: S-EPMC3637641 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature