Differential protein partitioning within the herpesvirus tegument and envelope underlies a complex and variable virion architecture.
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ABSTRACT:
SUBMITTER: Bohannon KP
PROVIDER: S-EPMC3637715 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Differential protein partitioning within the herpesvirus tegument and envelope underlies a complex and variable virion architecture.
Bohannon Kevin Patrick KP Jun Yonggun Y Gross Steven P SP Smith Gregory Allan GA
Proceedings of the National Academy of Sciences of the United States of America 20130408 17
The herpesvirus virion is a multilayered structure consisting of a DNA-filled capsid, tegument, and envelope. Detailed reconstructions of the capsid are possible based on its icosahedral symmetry, but the surrounding tegument and envelope layers lack regular architecture. To circumvent limitations of symmetry-based ultrastructural reconstruction methods, a fluorescence approach was developed using single-particle imaging combined with displacement measurements at nanoscale resolution. An analysi ...[more]
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