Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves.

ABSTRACT: Identification of markers of enteric neurons has contributed substantially to our understanding of the development, normal physiology, and pathology of the gut. Previously identified markers of the enteric nervous system can be used to label all or most neuronal structures or for examining individual cells by labeling just the nucleus or cell body. Most of these markers are excellent but have some limitations. Transmembrane protein 100 (TMEM100) is a gene at locus 17q32 encoding a 134-amino acid protein with two hypothetical transmembrane domains. TMEM100 expression has not been reported in adult mammalian tissues but does appear in the ventral neural tube of embryonic mice and plays a role in signaling pathways associated with development of the enteric nervous system. We showed that TMEM

SUBMITTER: Eisenman ST 

PROVIDER: S-EPMC3637859 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature