Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

ABSTRACT:

Background

Our previous studies indicated that N-methyl-D-aspartate receptor (NMDAR) deletion from a subset of corticolimbic interneurons in the mouse brain during early postnatal development is sufficient to trigger several behavioral and pathophysiological features resembling the symptoms of human schizophrenia. Interestingly, many of these behavioral phenotypes are exacerbated by social isolation stress. However, the mechanisms underlying the exacerbating effects of social isolation are unclear.

Methods

With γ-aminobutyric acid-ergic interneuron-specific NMDAR hypofunction mouse model (Ppp1r2-Cre/fGluN1 knockout [KO] mice), we investigated whether oxidative stress is implicated in the social isolation-induced exacerbation of schizophrenia-like phenotypes and further explo

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC3638045 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature