Clinical decision support for genetically guided personalized medicine: a systematic review.

ABSTRACT:

Objective

To review the literature on clinical decision support (CDS) for genetically guided personalized medicine (GPM).

Materials and methods

MEDLINE and Embase were searched from 1990 to 2011. The manuscripts included were summarized, and notable themes and trends were identified.

Results

Following a screening of 3416 articles, 38 primary research articles were identified. Focal areas of research included family history-driven CDS, cancer management, and pharmacogenomics. Nine randomized controlled trials of CDS interventions for GPM were identified, seven of which reported positive results. The majority of manuscripts were published on or after 2007, with increased recent focus on genotype-driven CDS and the integration of CDS within primary clinical information s

SUBMITTER: Welch BM 

PROVIDER: S-EPMC3638177 | biostudies-literature | 2013 Mar-Apr

REPOSITORIES: biostudies-literature