Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods.

ABSTRACT: Uncontrolled asthma is a major cause of hospitalizations and emergency room visits. Factors including obesity, African ancestry and childhood are associated with increased asthma severity. Considering the high morbidity caused by asthma, relatively few classes of drugs exist to control this common disease. Therefore, new therapeutic strategies may be needed to reduce asthma's impact on public health. Data suggest that a high fat diet that is deficient in omega-3 fatty acids could promote both obesity and excessive inflammation, resulting in greater asthma severity. Small trials with supplemental omega-3 fatty acids have been conducted with encouraging but inconsistent results. The variability in response seen in past trials may be due to the past subjects' genetics (specifically ALOX5 rs59

SUBMITTER: Lang JE 

PROVIDER: S-EPMC3638234 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature