Candidate cancer-targeting agents identified by expression-profiling arrays.

ABSTRACT:

Background

One particularly promising component of personalized medicine in cancer treatment is targeted therapy, which aims to maximize therapeutic efficacy while minimizing toxicity. However, the number of approved targeted agents remains limited. Expression microarray data for different types of cancer are resources to identify genes that were upregulated. The genes are candidate targets for cancer-targeting agents for future anticancer research and targeted treatments.

Methods and findings

The gene expression profiles of 48 types of cancer from 2,141 microarrays reported in the Gene Expression Omnibus were analyzed. These data were organized into 78 experimental groups, on which we performed comprehensive analyses using two-tailed Student's t-tests with significance set

SUBMITTER: Termglinchan V 

PROVIDER: S-EPMC3638713 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature