Sox10 is necessary for oligodendrocyte survival following axon wrapping.

ABSTRACT: Cells of the oligodendrocyte lineage, which form the myelinating glia of the vertebrate central nervous system, undergo a stepwise developmental progression entailing specification from neuroepithelial precursors, proliferation, migration to expand and distribute the population, and differentiation to ensheath axons with myelin. Understanding the genetic mechanisms that regulate each of these steps during development is important, because this might lead to therapies to promote remyelination following neural injury or disease. Genetic studies in mice indicated that the Sox10 transcription factor is required during the differentiation stage to promote myelin gene expression. However, whether Sox10 also promotes other features of oligodendroctye differentiation remained unknown. In this stud

SUBMITTER: Takada N 

PROVIDER: S-EPMC3639140 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature