Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update.

ABSTRACT:

Introduction

Leishmaniasis is an important public health problem in the Americas. A Cochrane review published in 2009 analyzed 38 randomized controlled trials (RCT). We conducted a systematic review to evaluate the effects of therapeutic interventions for American cutaneous and mucocutaneous leishmaniasis.

Methods

All studies were extracted from PubMed, Embase, Lilacs (2009 to July, 2012 respectively), the Cochrane Central Register of Controlled Trials (6-2012) and references of identified publications. RCTs' risk of bias was assessed.

Results

We identified 1865 references of interest; we finally included 10 new RCTs. The risk of bias scored low or unclear for most domains. Miltefosine was not significantly different from meglumine antimoniate in the complete cure rat

SUBMITTER: Reveiz L 

PROVIDER: S-EPMC3639260 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature