Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.

ABSTRACT: Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy to a potent anxiolytic inhibiting voltage dependent calcium channels (VOCCs) as highly selective drug target. In contrast to previous publications where exorbitant high concentrations were used, the effects of lavender oil in behavioral, biochemical, and electrophysiological experiments were investigated in physiological concentrations in the nanomolar range, which correlate to a single dosage of 80 mg/d in humans that was used in clinical trials. We show for the first time that lavender oil bears some similarities with the established anx

SUBMITTER: Schuwald AM 

PROVIDER: S-EPMC3639265 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature