Refinement of neuronal synchronization with gamma oscillations in the medial prefrontal cortex after adolescence.

ABSTRACT: The marked anatomical and functional changes taking place in the medial prefrontal cortex (PFC) during adolescence set grounds for the high incidence of neuropsychiatric disorders with adolescent onset. Although circuit refinement through synapse pruning may constitute the anatomical basis for the cognitive differences reported between adolescents and adults, a physiological correlate of circuit refinement at the level of neuronal ensembles has not been demonstrated. We have recorded neuronal activity together with local field potentials in the medial PFC of juvenile and adult mice under anesthesia, which allowed studying local functional connectivity without behavioral or sensorial interference. Entrainment of pyramidal neurons and interneurons to gamma oscillations, but not to theta or b

SUBMITTER: de Almeida J 

PROVIDER: S-EPMC3639907 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature