Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins.

ABSTRACT:

Background

Copy number variations (CNVs) are widespread in the human or animal genome and are a significant source of genetic variation, which has been demonstrated to play an important role in phenotypic diversity. Advances in technology have allowed for identification of a large number of CNVs in cattle. Comprehensive explore novel CNVs in the bovine genome would provide valuable information for functional analyses of genome structural variation and facilitating follow-up association studies between complex traits and genetic variants.

Results

In this study, we performed a genome-wide CNV detection based on high-density SNP genotyping data of 96 Chinese Holstein cattle. A total of 367 CNV regions (CNVRs) across the genome were identified, which cover 42.74 Mb of the cattle

SUBMITTER: Jiang L 

PROVIDER: S-EPMC3639935 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature