A fourteen gene GBM prognostic signature identifies association of immune response pathway and mesenchymal subtype with high risk group.

ABSTRACT:

Background

Recent research on glioblastoma (GBM) has focused on deducing gene signatures predicting prognosis. The present study evaluated the mRNA expression of selected genes and correlated with outcome to arrive at a prognostic gene signature.

Methods

Patients with GBM (n = 123) were prospectively recruited, treated with a uniform protocol and followed up. Expression of 175 genes in GBM tissue was determined using qRT-PCR. A supervised principal component analysis followed by derivation of gene signature was performed. Independent validation of the signature was done using TCGA data. Gene Ontology and KEGG pathway analysis was carried out among patients from TCGA cohort.

Results

A 14 gene signature was identified that predicted outcome in GBM. A weighted gene (WG)

SUBMITTER: Arimappamagan A 

PROVIDER: S-EPMC3639942 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature